Conversion of Δ7-Cholestenol-4-C14 and 7-Dehydrocholesterol-4-C14 to Cholesterol

Metabolism of Coprostanol-c14 and Cholestanol-4-c14 in Man.

The conversion of cholesterol-4-C14 to acids and other products by liver mitochondria.

Since the finding by Bloch, Berg, and Rittenberg that rholesterol could be converted to cholic acid in the dog (l), several groups have established bile acids to be the primary end-product of cholesterol degradation by the liver in the intact rat (2,3), rabbit (4), and human (5). Most of the steps involved in the conversion are still unknown, although the experiments of Zabin and Barker (6) and...

Biogenesis of estrogens by the human ovary. III. Conversion of cholesterol-4-C14 to estrone.

Although cholesterol has been accepted as a precursor of the neutral steroid hormones, its role in estrogen formation has been subject to much doubt. It was postulated, on the basis of experiments in z&o in the pregnant mare, that cholesterol was not an estrogen precursor (1). The test animal had readily converted radioactive acetate to labeled estrogens, but had failed to convert administered ...

The incorporation of formate-C14, glycine-2-C14, adenine-4, 6-C14, and phosphate-P32 into nucleic acids.

nine labeled either with C'4 or N'5. Considerable controversy has developed as to which one of these tracer compounds gives an accurate measurement of the “relativeturnover-rate― of the nucleic acids. In order to determine the “absolute turnover rate― of the nucleic acids, it is necessary to know the specific activity of the immediate precursor of the nucleic acids. Since even the ident...

The conversion of testosterone-3-C14 to C14-estradiol-17beta by human ovarian tissue.

There is a considerable body of biological data linking testosterone and other 19-carbon steroids with the estrogens. Both ovaries and testes may, under certain circumstances, produce androgens and estrogens (14). The administration of testosterone and other androgens to human subjects leads to an increased urinary excretion of estrogenic material (5-lo), which has been identified as estrone, e...